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The Team
The Team
Publications
Anchor 2
Monteran L, Ershaid N, Scharff Y, Zoabi Y, Sanalla T, Ding Y, Pavlovsky A, Zait Y, Langer M, Caller T, Eldar-Boock A, Avivi C, Sonnenblick A, Satchi-Fainaro R, Barshack I, Shomron N, Zhang X and Erez N. Combining TIGIT blockade with MDSC inhibition hinders breast cancer bone metastasis by activating anti-tumor immunity. Cancer Discov. 2024 Mar 1. doi: 10.1158/2159-8290.CD-23-0762. Online ahead of print. PMID: 38427556. PDF
Shapir Itai Y, Barboy O, Salomon R, Bercovich A, Xie K, Winter E, Shami T, Porat Z, Erez N,
Tanay A, Amit A, and Dahan R. Bispecific Immune Synapse Engager mediates dendritic-T cell
interactions resulting in potent anti-tumor immunity. Cell. 2024 Jan 18;187(2):375-389.e18. PDF
Yofe I*, Shami T*, Cohen N*, Landsberger T, Sheban F, Stoler-Barak L, Yalin A, San Phan T, Li B,
Monteran L, Scharff Y, Giladi A, Elbaz M, David E, Gurevich-Shapiro A, Gur C, Shulman Z, Erez
N # , Amit I # . Spatial and temporal mapping of breast cancer lung metastases identify TREM2
macrophages as regulators of the metastatic boundary. Cancer Discov. 2023 Sep 27. PDF.
# Corresponding Author.
Cohen N*, Mundhe D*, Deasy SK*, Adler O, Ershaid N, Shami T, Levi-Galibov O, Wassermann
R, Scherz-Shouval R, and Erez N. Systemic signaling by breast cancer secreted factors
promotes lung metastasis by inducing a fibrotic pre-metastatic niche. Cancer Res. 2023 Aug 7. PDF.
Goldman O, Adler LN, Hajaj E, Croese T, Darzi N, Galai S, Tishler H, Ariav Y, Lavie D, Fellus-
Alyagor L, Oren R, Kuznetsov Y, David E, Jaschek R, Stossel C, Singer O, Malitsky S, Barak R,
Seger R, Erez N, Amit I, Tanay A, Saada A, Golan T, Rubinek T, Sang Lee J, Ben-Shachar S,
Wolf I, and Erez A. Early infiltration of innate immune cells to the liver depletes HNF4a and
promotes extra-hepatic carcinogenesis. Cancer Discov. 2023 Mar 27. PDF.
Adler O*, Zait Y*, Cohen N, Blazquez R, Doron H, Monteran L, Scharff Y, Shami T, Mundhe D, Glehr G, Kanner AA, Horn S, Yahalom V, Haferkamp S, Hutchinson JA, Bleckmann A, Nahary L, Benhar I, Yust Katz S, Pukrop T and Erez N. Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via Lipocalin-2. Nature Cancer, February 16 2023. PDF.
Monteran L, Ershaid E, Sabah I, Fahoum I, Zait Y, Shani O, Cohen N, Eldar-Boock A, Satchi-Fainaro R, and Erez N. Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis. Sci Rep. 2020 Aug 14;10(1):13838. PDF
Shani O, Raz Y, Monteran L, Scharff Y, Levi-Galibov O, Megides O, Shacham H, Cohen N, Silverbush D, Avivi C, Sharan R, Madi A, Scherz-Shouval R, Barschak I, Tsarfaty I, and Erez N. Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity. 2021. eLife. PDF
Ershaid N, Sharon Y, Doron H, Raz Y, Shani O, Cohen N, Monteran L, Leider-Trejo L, Ben-Shmuel A, Yassin M, Gerlic M, Ben-Baruch A, Pasmanik-Chor M, Apte R and Erez N. NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis. Nat Commun. 2019;10(1):4375. PDF
Doron H, Amer M, Ershaid N, Blazquez R, Shani O, Gener Lahav T, Cohen N, Adler O, Hakim Z, Pozzi S, Scomparin A, Cohen J, Yassin M, Monteran L, Grossman R, Tsarfaty G, Luxenburg C, Satchi-Fainaro R, Pukrop T and Erez N. Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis. Cell Reports. 2019;28(7):1785-1798.e6. PDF
Gener Lahav T, Adler O, Zait Y, Shani O, Amer M, Doron H, Abramovitz L, Yofe I, Cohen N and Erez N. Melanoma-derived extracellular vesicles instigate proinflammatory signaling in the metastatic microenvironment. IJC. 2019;145(9):2521-2534. PDF
Cohen N and Erez N. FACS Analysis of Col1α Protein Levels in Primary Fibroblasts. Methods Mol Biol. 2019;1944:221-228. PDF
Raz Y, Cohen N, Shani O, Bell RE, Novitskiy SV, Abramovitz L, Levy C, Milyavsky M, Leider-Trejo L, Moses HL, Grisaru D and Erez N. Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer. Journal of Experimental Medicine. 2018;215(12):3075-3093. PDF
Ben Baruch B, Blacher E, Mantsur E, Schwartz H, Vaknine H, Erez N, and Stein R. Stromal CD38 regulates outgrowth of primary melanoma and generation of spontaneous metastasis. Oncotarget, 9(61), 31797-31811. PDF
Blau R, Epshtein Y, Pisarevsky E, Tiram G, Israeli Dangoor S, Yeini E, Krivitsky A, Eldar-Boock A, Ben-Shushan D, Gibori H, Scomparin A, Green O, Ben-Nun Y, Merquiol E, Doron H, Blum G, Erez N, Grossman R, Ram Z, Shabat D and Satchi-Fainaro R. Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins. Theranostics, 8(13), 3437-3460. PDF
Herkel J, Schrader J, Erez N, Lohse A and Cohen IR. Activation of the Akt-CREB signaling axis by a proline-rich heptapeptide confers resistance to stress-induced cell-death and inflammation. Immunology. 2017 Apr 17. PDF
Monteran L, Ershaid N, Doron H, Zait Y, Scharff Y, Ben-Yosef S, Avivi C, Barshack I, Sonnenblick A and Erez N. Chemotherapy-induced complement signaling modulates immunosuppression and metastatic relapse in breast cancer. Nat Commun. 2022 Oct 2;13(1):5797. PDF
Shani O, Vorobyov T, Monteran L, Lavie D, Cohen N, Raz Y, Tsarfaty G, Avivi C, Barshack I and Erez N. Fibroblast-derived IL-33 facilitates breast cancer metastasis by modifying the immune microenvironment and driving type-2 immunity. Cancer Res. 2020 Oct 6:canres.2116.2020. PDF
Klein A, Sagi-Assif O, Meshel T, Telerman A, Izraely S, Ben-Menachem S, Bayry J, Marzese D, Ohe S, Hoon D, Erez N and Witz I. CCR4 is a determinant of melanoma brain metastasis. Oncotarget. 2017 Mar 10. PDF
Cohen N, Shani O, Raz Y, Sharon Y, Hoffman D, Abramovitz L and Erez N. Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1. Oncogene. 2017 Apr 3. PDF
Dror S, Sander L, Schwartz H, Sheinboim D, Barzilai A, Dishon Y, Apcher S, Golan T, Greenberger S, Barshack I, Malcov H, Zilberberg A, Levin L, Nessling M, Friedmann Y, Igras V, Barzilay O, Vaknine H, Brenner R, Zinger A, Schroeder A, Gonen P, Khaled M, Erez N, Hoheisel JD and Levy C. Melanoma miRNA trafficking triggers tumor primary niche formation. Nature Cell Biology. 2016 Sep;18(9):1006-17. PDF
Schwartz H, Blacher E, Amer M, Livneh N, Abramovitz L, Klein A, Ben-Shushan D, Soffer S, Blazquez R, Barrantes-Freer A, Müller M, Müller-Decker K, Stein R, Tsarfaty G, Satchi-Fainaro R, Umansky V, Pukrop T and Erez N. Incipient melanoma brain metastases instigate astrogliosis and neuroinflammation. Cancer Res. 2016 Aug 1;76(15):4359-71. PDF
Rietkötter E, Bleckmann A, Bayerlowa M, Menck K, Chuang H-N, Wenske B, Schwartz H, Erez N, Binder C, Hanisch U-K, and Pukrop T. Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells (MCs) but scarcely by microglia. Oncotarget. 2015 Jun 20;6(17):15482-93. PDF
Klein A, Schwartz H, Sagi-Assif O, Meshel T, Izraely S, Ben Menachem S, Bengaiev R, Ben-shmuel A, Nahmias C, Couraud PO, Witz IP, Erez N. Astrocytes facilitate melanoma brain metastasis via secretion of IL-23. J Pathol. 2015 May;236(1):116-27. PDF
Sharon Y, Raz Y, Cohen N, Ben-Shmuel A, Schwartz H, Geiger T and Erez N. Tumor-derived Osteopontin reprograms normal mammary fibroblasts to promote inflammation and tumor growth in breast cancer. Cancer Res. 2015 Mar 15;75(6):963-73. PDF
Erez N, Glanz S, Raz Y, Avivi C, and Barshack I. Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors. Biochem Biophys Res Commun. 2013 Aug 2;437(3):397-402. PDF
Sharon Y, Alon L, Glanz S, Servais S and Erez N. Isolation of Normal and Cancer-Associated Fibroblasts from fresh tissues by Fluorescence Activated Cell Sorting (FACS). J Vis Exp. 2013 Jan 14;(71):e4425 PDF
Klein A, Sagi-Assif O, Izraely S, Meshel T, Pasmanik-Chor M, Nahmias C, Couraud PO, Erez N, Hoon DSB and Witz IP. The metastatic microenvironment. Brain-derived soluble factors alter the malignancy phenotype of cutaneous and brain- metastasizing melanoma cells. Int J Cancer. 2012 Dec 1;131(11):2509-18 PDF
Erez N, Truitt M, Olson P, and Hanahan D. Cancer Associated Fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kB-dependent manner. Cancer Cell. 2010 Feb 17;17(2):135-47.(Featured in: Cancer Cell 2010, February; 17 (2): 111-112). PDF
Pahler JC, Tazzyman S, Erez N, Chen Y, Murdoch C, Nozawa H, Lewis C, Hanahan D. Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia. 2008 Apr;10(4):329-40. PDF
Efrati S, Berman S, Goldfinger N, Erez N, Averbukh Z, Golik A, Rotter V, and Weissgarten J. Enhanced angiotensin II production by renal mesangium is responsible for apoptosis/proliferation of endothelial and epithelial cells in a model of malignant hypertension. J Hypertens. 2007 May;25(5):1041-52 PDF
Milyavsky M, Tabach Y, Shats I, Erez N, Cohen Y, Tang X, Kalis M, Kogan I, Buganim Y, Goldfinger N, Ginsberg D, Harris CC, Domany E, and Rotter V. Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation. Cancer Res. 2005 Jun 1;65(11):4530-43. PDF
Herkel J, Kam N, Erez N, Mimran A, Heifetz A, Eisenstein M, Rotter V and Cohen IR. Monoclonal antibody to a DNA-binding domain of p53 mimics charge structure of DNA: anti-idiotypes to the anti-p53 antibody are anti-DNA. Eur J Immunol. 2004 Dec;34(12):3623-32. PDF
Shats I, Milyavsky M, Tang X, Stambolsky P, Erez N, Brosh R, Kogan I, Braunstein I, Tzukerman M, Ginsberg D and Rotter V. p53-dependent downregulation of telomerase is mediated by p21/waf1. J Biol Chem. 2004 Dec 3;279(49):50976-85. PDF
Tang X, Milyavsky M, Shats I, Erez N, Goldfinger N and Rotter V. Activated p53 suppresses the histone methyltransferase EZH2 gene. Oncogene. 2004 Jul 29;23(34):5759-69. PDF
Erez N, Stambolsky P, Shats I, Milyavsky M, Kachko T and Rotter V. Hypoxia-dependent regulation of PHD1: Cloning and Characterization of the human PHD1/EGLN2 gene promoter. FEBS Lett. 2004 Jun 4;567(2-3):311-5. PDF
Erez N, Milyavsky M, Eilam R, Shats I, Goldfinger N, and Rotter V. Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth. Cancer Res. 2003 Dec 15;63(24):8777-83. PDF
Milyavsky M, Shats I, Erez N, Tang X, Senderovich S, Meerson A, Tabach Y, Goldfinger N, Ginsberg D, Harris CC and Rotter V. Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res. 2003 Nov 1;63(21):7147-57. PDF
Shats I, Milyavsky M, Erez N and Rotter V. The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein. FEBS Lett. 2003 Jul 10;546(2-3):321-4. PDF
Erez N, Milyavsky M, Goldfinger N, Peles E, Gudkov AV and Rotter V. Falkor, A Novel Cell Growth Regulator Isolated by a Functional Genetic Screen. Oncogene 2002. Oct 3;21(44):6713-21. PDF
Offer I, Erez N, Zurer I, Tang X, Milyavsky M, Goldfinger N and Rotter V. The onset of p53-dependent DNA repair or apoptosis is dependent on DNA damaging levels. Carcinogenesis. 2002 23 (6):1025-1032 PDF
Milyavsky M, Mimran A, Senderovich S, Zurer I, Erez N, Shats I, Goldfinger N, Cohen I and Rotter V. Activation of p53 protein by telomeric (TTAGGG)(n) repeats. Nucleic Acids Res. 2001 Dec 15;29(24):5207-15. PDF
Herkel J, Mimran A, Erez N, Kam N, Lohse AW, Märker-Hermann E, Rotter V and Cohen IR. Autoimmunity to the p53 Protein is a Feature of Systemic Lupus Erythematosus (SLE) Related to Anti-DNA Antibodies. J Autoimmunity. 2001 17, pp. 63-69. PDF
Offer H, Milyavsky M, Erez N, Matas D, Zurer I, Harris CH and Rotter V. Structural and functional involvement of p53 in BER in vitro and in vivo. Oncogene. 2001 (20): 581-589. PDF
Herkel J, Erez-Alon N, Wolkowicz R, Harmelin A, Ruiz PJ, Rotter V and Cohen IR. Systemic lupus erythematosus in mice, spontaneous and induced, is associated with autoimmunity to the C-terminus domain of p53 that recognizes damaged DNA. Eur J Immunol. 2000 Apr;30(4):977-984. PDF
Erez-Alon N, Herkel J, Wolkowicz R, Ruiz PJ, Waisman A, Rotter V and Cohen IR. Immunity to p53 induced by an idiotypic network of anti-p53-antibodie: Generation of sequence-specific anti-DNA antibodies and protection from tumor metastasis. Cancer Res. 1998. 58, 5447-5452. PDF
Anchor 1
Monteran L, Zait Y, Erez N. It's all about the base: stromal cells are central orchestrators of
metastasis. Trends Cancer. 2023 Dec 9. PDF
Erez N. Location, location: understanding the metastatic microenvironment. Mol Oncol. 2023 Jul
20. PDF
Monteran L and Erez N. myCAFs are better than yours: targeting myofibroblasts potentiates immunotherapy. Trends Cancer. 2022 November 9. PDF
Lavie D, Ben Shmuel A, Erez N and Scherz-Shouval R. Cancer-associated fibroblasts in the single-cell era. Nat Cancer. 2022 Jul 26. PDF
Speah S and Erez N. A glitch in the matrix: organ-specific matrisomes in metastatic niches. Trends Cell Biol. 2021 Sep 1. PDF
Monteran L and Erez N. The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment. Front Immunol. 2019 Aug 2. PDF
Hila Doron, Tobias Pukrop and Neta Erez. A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis. Cancer Res. January 24 2019. PDF
Erez N. Fibroblasts form a hospitable metastatic niche in the liver. Nat Cell Biol. 2016 Apr 27. PDF
Erez N. Cancer: Opening LOX to metastasis. Nature. 2015 May 27. PDF
Erez N. Cancer: Angiogenic Awakening. Nature. 2013 Jul 24. PDF
Raz Y and Erez N. An inflammatory vicious cycle: fibroblasts and immune cell recruitment in cancer. Exp Cell Res. 2013 Apr 5. PDF
Servais C and Erez N. From Sentinel Cells to Inflammatory Culprits: Cancer-Associated Fibroblasts in Tumor-related Inflammation. J Pathol. 2013 Jan. PDF
Erez N and Coussens LM. Leukocytes as Paracrine Regulators of Metastasis and Determinants of Organ-Specific Colonization. Int J Cancer. 2011 Jun 1;128(11):2536-44. PDF
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